CEBPD

Protein-coding gene in the species Homo sapiens
CEBPD
Identifiers
AliasesCEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
External IDsOMIM: 116898 MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CEBPD
Genomic location for CEBPD
Band8q11.21Start47,736,913 bp[1]
End47,738,164 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for CEBPD
Genomic location for CEBPD
Band16 A2|16 10.09 cMStart15,705,150 bp[2]
End15,708,895 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • vena cava

  • lower lobe of lung

  • trachea

  • cardia

  • olfactory bulb

  • gastric mucosa

  • trigeminal ganglion

  • parotid gland

  • left uterine tube
Top expressed in
  • left lung lobe

  • belly cord

  • right lung

  • carotid body

  • ankle

  • ankle joint

  • right lung lobe

  • external carotid artery

  • triceps brachii muscle

  • thoracic diaphragm
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • protein homodimerization activity
  • protein heterodimerization activity
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • cytokine-mediated signaling pathway
  • hematopoietic progenitor cell differentiation
  • regulation of transcription by RNA polymerase II
  • fat cell differentiation
  • positive regulation of osteoblast differentiation
  • negative regulation of transcription, DNA-templated
  • inner ear development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1052

12609

Ensembl

ENSG00000221869

ENSMUSG00000071637

UniProt

P49716

Q00322

RefSeq (mRNA)

NM_005195

NM_007679

RefSeq (protein)

NP_005186

NP_031705

Location (UCSC)Chr 8: 47.74 – 47.74 MbChr 16: 15.71 – 15.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[11]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000221869 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071637 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
  6. ^ Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
  7. ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
  8. ^ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331. S2CID 24347537.
  9. ^ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
  10. ^ Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, Győrffy B (2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy: Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC 5056990. PMID 27673562.
  11. ^ Choy L, Derynck R (Mar 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–19. doi:10.1074/jbc.M212259200. PMID 12524424.

Further reading

  • Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
  • Kinoshita S, Akira S, Kishimoto T (Feb 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–6. Bibcode:1992PNAS...89.1473K. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
  • Nagulapalli S, Pongubala JM, Atchison ML (Nov 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–8. doi:10.4049/jimmunol.155.9.4330. PMID 7594592.
  • Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168.
  • Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.
  • Chen PL, Riley DJ, Chen Y, Lee WH (Nov 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.
  • Xia C, Cheshire JK, Patel H, Woo P (Dec 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
  • Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
  • Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E (Dec 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. hdl:11382/3170. PMID 11851384. S2CID 8215328.
  • Gao H, Parkin S, Johnson PF, Schwartz RC (Oct 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
  • Dearth LR, DeWille J (Mar 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
  • Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852. S2CID 45020949.
  • Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (Sep 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
  • Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (Dec 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. S2CID 9817319.
  • Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (Sep 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging. 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823. S2CID 54232508.
  • Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (Nov 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878. S2CID 31572695.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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