GTF3C1

Protein-coding gene in the species Homo sapiens
GTF3C1
Identifiers
AliasesGTF3C1, TFIIIC, TFIIIC220, TFIIICalpha, general transcription factor IIIC subunit 1
External IDsOMIM: 603246 MGI: 107887 HomoloGene: 31040 GeneCards: GTF3C1
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for GTF3C1
Genomic location for GTF3C1
Band16p12.1Start27,459,555 bp[1]
End27,549,913 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for GTF3C1
Genomic location for GTF3C1
Band7 F3|7 69.01 cMStart125,240,126 bp[2]
End125,306,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • skin of abdomen

  • sural nerve

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • stromal cell of endometrium

  • right uterine tube

  • ganglionic eminence

  • gastrocnemius muscle

  • nucleus accumbens
Top expressed in
  • spermatocyte

  • internal carotid artery

  • external carotid artery

  • superior frontal gyrus

  • entorhinal cortex

  • secondary oocyte

  • corneal stroma

  • spermatid

  • ganglionic eminence

  • extensor digitorum longus muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA polymerase III general transcription initiation factor activity
  • RNA polymerase III type 1 promoter sequence-specific DNA binding
  • RNA polymerase III type 2 promoter sequence-specific DNA binding
Cellular component
  • transcription factor TFIIIC complex
  • nucleolus
  • membrane
  • nucleus
  • nucleoplasm
  • ribonucleoprotein complex
Biological process
  • tRNA transcription by RNA polymerase III
  • rRNA transcription
  • tRNA transcription
  • transcription, DNA-templated
  • transcription by RNA polymerase III
  • regulation of transcription by RNA polymerase III
  • transcription initiation from RNA polymerase III promoter
  • 5S class rRNA transcription by RNA polymerase III
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2975

233863

Ensembl

ENSG00000077235

ENSMUSG00000032777

UniProt

Q12789

Q8K284

RefSeq (mRNA)

NM_001286242
NM_001520

NM_207239

RefSeq (protein)

NP_001273171
NP_001511

NP_997122

Location (UCSC)Chr 16: 27.46 – 27.55 MbChr 7: 125.24 – 125.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.[5][6][7]

Interactions

GTF3C1 has been shown to interact with GTF3C4.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077235 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032777 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol. Cell. Biol. 14 (5): 3053–64. doi:10.1128/mcb.14.5.3053. PMC 358673. PMID 8164661.
  6. ^ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1652–6. Bibcode:1994PNAS...91.1652L. doi:10.1073/pnas.91.5.1652. PMC 43221. PMID 8127861.
  7. ^ "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa".
  8. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
  • Kovelman R, Roeder RG (1992). "Purification and characterization of two forms of human transcription factor IIIC". J. Biol. Chem. 267 (34): 24446–56. doi:10.1016/S0021-9258(18)35787-9. PMID 1447193.
  • Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
  • Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  • Meissner W, Thomae R, Seifart KH (2002). "The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells". J. Biol. Chem. 277 (9): 7148–56. doi:10.1074/jbc.M108721200. PMID 11741993.
  • Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC". Cell Death Differ. 9 (4): 439–47. doi:10.1038/sj.cdd.4401038. PMID 11965497.
  • Weser S, Riemann J, Seifart KH, Meissner W (2003). "Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene". Nucleic Acids Res. 31 (9): 2408–16. doi:10.1093/nar/gkg345. PMC 154231. PMID 12711686.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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