ZNF143

Protein-coding gene


ZNF143
Identifiers
AliasesZNF143, SBF, STAF, pHZ-1, zinc finger protein 143
External IDsOMIM: 603433 MGI: 1277969 HomoloGene: 56444 GeneCards: ZNF143
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ZNF143
Genomic location for ZNF143
Band11p15.4Start9,460,319 bp[1]
End9,528,524 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ZNF143
Genomic location for ZNF143
Band7 E3|7 57.7 cMStart109,660,424 bp[2]
End109,694,601 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • monocyte

  • islet of Langerhans

  • endothelial cell

  • secondary oocyte

  • gastrocnemius muscle

  • popliteal artery

  • canal of the cervix

  • blood
Top expressed in
  • morula

  • ganglionic eminence

  • blood

  • abdominal wall

  • secondary oocyte

  • thymus

  • atrioventricular valve

  • medial ganglionic eminence

  • primitive streak

  • superior cervical ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleic acid binding
  • DNA binding
  • protein binding
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase III
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • transcription by RNA polymerase III
  • snRNA transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7702

20841

Ensembl

ENSG00000166478

ENSMUSG00000061079

UniProt

P52747

O70230

RefSeq (mRNA)

NM_001282656
NM_001282657
NM_003442

NM_009281
NM_001374618

RefSeq (protein)

NP_001269585
NP_001269586
NP_003433

NP_033307
NP_001361547
NP_001392700
NP_001392701

Location (UCSC)Chr 11: 9.46 – 9.53 MbChr 7: 109.66 – 109.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166478 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061079 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZNF143 zinc finger protein 143".

Further reading

  • Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
  • Schuster C, Myslinski E, Krol A, Carbon P (1995). "Staf, a novel zinc finger protein that activates the RNA polymerase III promoter of the selenocysteine tRNA gene". EMBO J. 14 (15): 3777–87. doi:10.1002/j.1460-2075.1995.tb00047.x. PMC 394452. PMID 7641696.
  • Schaub M, Myslinski E, Schuster C, et al. (1997). "Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III". EMBO J. 16 (1): 173–81. doi:10.1093/emboj/16.1.173. PMC 1169624. PMID 9009278.
  • Schuster C, Krol A, Carbon P (1998). "Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters". Mol. Cell. Biol. 18 (5): 2650–8. doi:10.1128/mcb.18.5.2650. PMC 110644. PMID 9566884.
  • Myslinski E, Krol A, Carbon P (1998). "ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf". J. Biol. Chem. 273 (34): 21998–2006. doi:10.1074/jbc.273.34.21998. PMID 9705341.
  • Rincon JC, Engler SK, Hargrove BW, Kunkel GR (1998). "Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter". Nucleic Acids Res. 26 (21): 4846–52. doi:10.1093/nar/26.21.4846. PMC 147939. PMID 9776743.
  • Mach CM, Hargrove BW, Kunkel GR (2002). "The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene". J. Biol. Chem. 277 (7): 4853–8. doi:10.1074/jbc.M108308200. PMID 11724783.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Grossman CE, Qian Y, Banki K, Perl A (2004). "ZNF143 mediates basal and tissue-specific expression of human transaldolase". J. Biol. Chem. 279 (13): 12190–205. doi:10.1074/jbc.M307039200. PMID 14702349.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wakasugi T, Izumi H, Uchiumi T, et al. (2007). "ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes". Oncogene. 26 (36): 5194–203. doi:10.1038/sj.onc.1210326. PMID 17297437. S2CID 21482216.
  • Myslinski E, Gérard MA, Krol A, Carbon P (2007). "Transcription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143". Nucleic Acids Res. 35 (10): 3453–64. doi:10.1093/nar/gkm239. PMC 1904299. PMID 17478512.
  • Gérard MA, Krol A, Carbon P (2007). "Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene". Gene. 401 (1–2): 145–53. doi:10.1016/j.gene.2007.07.011. PMID 17707600.
  • Yuan CC, Zhao X, Florens L, et al. (2007). "CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription". Mol. Cell. Biol. 27 (24): 8729–38. doi:10.1128/MCB.00846-07. PMC 2169411. PMID 17938208.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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